افزایش بروز ژن P53 در سرطان ترانزیشنال مثانه

ABSTRACT Bladder cancer consists of about 5.2% of all cancers in men and 2.3% in women. About 90% of them have the origin of transitional cells(TCC). There are some predictive factors that knowledge of them is useful for management and follow-up of the patients. Expression of oncoprotein P53 is one of these factors. Considering influence of P53 expression on prognosis, we decided to study the correlations between tumor grade and stage with P53. Whereas these correlations to be found, the clinician may treat their patients, with high-grade and invasive tumor with P53 expression, aggressively and earlier, without any need to stain for P53. In our study we reviwed 27 patients in shahid Hashemi-Nejad hospital that 12 of them had low-grade urothelial carcinoma and the others had high-grade urothelial carcinoma according to WHO/ISUP system. Also 7 patients had invasive tumors and 20 of them had superficial tumors. After immunohistochemistry staining for P53, all the high-grade and invasive tumors were positive with the cut-off of 10%. But there was no meaningful statistical correlation between superficial and low-grade tumors and P53 expression. Obtained Pvalue with Fisher’s test for P53 expression and tumor grade and stage were 0.028 and 0.018 respectively and with Spearman test were 46% and 50% respectively.